The fixture log has been posted by the FAZ media crew on its Facebook page.
Zesco United will face South African side Kaizer Chiefs while Nkana will play San Pedro of Ivory Coast.
Both Zambian sides will be at home in the first legs on the weekend of January 11-13.
Zesco United fell off to the Confederation Cup after losing 2-1 on aggregate to TP Mazembe while Nkana was eliminated by Simba of Tanzania.
Nkana beat Simba 2-1 at home but lost 3-1 in the second leg to drop to the Confederation Cup.
Kaizer Chiefs will be making their first trip to Zambia since 2000 when they faced Nchanga Rangers of Chingola in the round of 16 ties that ended 0-0.
Zambia’s other continental envoys Green Buffaloes and Green Eagles crashed out of the CAF Confederations Cup at the hands of SC Sfaxien and Dey Hussein in that order.