For a second successive season, Zesco will meet a South African club in the final knockout phase of a CAF inter-club competition.
Zesco will face SuperSport United of South Africa in September in the quarterfinals of the 2017 CAF Confederation Cup.
SuperSport will also be their second successive Pretoria opponent they will play in continental football at this stage.
Zesco were eliminated 3-2 on aggregate after a 2-0 away,final leg defeat from the 2016 CAF Champions League semifinals by the defending champions Mamelodi Sundowns en route to winning their debut continental title.
SuperSport will host Zesco in Pretoria in the first leg on September 9 and travel to Ndola for the final leg on September 16.
They will face either MC Alger of Algeria or 2011 runners-up Club Africain of Tunisia in the semifinals.
But Zambia’s interest in the CAF Confederation Cup spills across the border into DR Congo where Confederation Cup defending champions TP Mazembe will face Zesco’s ex-Group C opponents CRD Libolo of Angola.
Mazembe’s Chipolopolo regulars include Rainford Kalaba and Nathan Sinkala,the latter scoring the decisive goal in their 2-1 home win over Horoya of Guinea last Saturday to see them through to the last 8.
Holders Mazembe will be away in Calulo for the first leg that same weekend.
Winner will face victor of the North African derby involving record 3-time Confederation Cup champions CS Sfaxien of Tunisia and 2010 champions FUS Rabat of Morocco in the semifinals.